Toward aldehyde and alkane production by removing aldehyde reductase activity in Escherichia coli

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Isobutyraldehyde production from Escherichia coli by removing aldehyde reductase activity

BACKGROUND Increasing global demand and reliance on petroleum-derived chemicals will necessitate alternative sources for chemical feedstocks. Currently, 99% of chemical feedstocks are derived from petroleum and natural gas. Renewable methods for producing important chemical feedstocks largely remain unaddressed. Synthetic biology enables the renewable production of various chemicals from microo...

متن کامل

Pig muscle aldehyde reductase. Identity of pig muscle aldehyde reductase with pig lens aldose reductase and with the low Km aldehyde reductase of pig brain and pig kidney.

A monomeric (Mr = 43,000) NADPH-dependent oxidoreductase with a broad substrate specificity for aliphatic and aromatic aldehydes and aldo sugars has been purified from the skeletal muscle of female and castrated pigs. The properties of this enzyme are consistent with those of aldose reductase (EC 1.1.1.21), and the enzyme is immunologically identical with aldose reductase from pig lens. However...

متن کامل

Functional screening of aldehyde decarbonylases for long-chain alkane production by Saccharomyces cerevisiae

BACKGROUND Low catalytic activities of pathway enzymes are often a limitation when using microbial based chemical production. Recent studies indicated that the enzyme activity of aldehyde decarbonylase (AD) is a critical bottleneck for alkane biosynthesis in Saccharomyces cerevisiae. We therefore performed functional screening to identify efficient ADs that can improve alkane production by S. c...

متن کامل

Aldose reductase-catalyzed reduction of aldehyde phospholipids.

Oxidation of unsaturated phospholipids results in the generation of aldehyde side chains that remain esterified to the phospholipid backbone. Such "core" aldehydes elicit immune responses and promote inflammation. However, the biochemical mechanisms by which phospholipid aldehydes are metabolized or detoxified are not well understood. In the studies reported here, we examined whether aldose red...

متن کامل

Photoassisted Alkane Activation under CO Atmosphere: Observation of Aldehyde, Alkene, and Activated Alkane

Direct observation of carbonylated and dehydrogenated products from cyclohexane was made via in situ FTIR monitored reaction of half-sandwich iridium dicarbonyl metal centers under carbon monoxide atmosphere. Variation of pressure in semibatch experiments allows for the detection of aldehydes as well as alkene. Changing atmosphere from carbon monoxide to compressed air resulted in ketone format...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Metabolic Engineering

سال: 2014

ISSN: 1096-7176

DOI: 10.1016/j.ymben.2014.07.012